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Index > Protein center > CNR1(Gene name) > Human
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  • CNR1 (Gene name),
  • Cannabinoid receptor 1 (Protein name ),  CNR1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CNR1(CNR);
    Protein name:
    Cannabinoid receptor 1(CB-R;CB1);
    Alternative:
    CANN6;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts (via C-terminus) with CNRIP1.
    Function:
    Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    472
    Sequence:
    50:
    MKSILDGLAD | TTFRTITTDL | LYVGSNDIQY | EDIKGDMASK | LGYFPQKFPL | 
    100:
    TSFRGSPFQE | KMTAGDNPQL | VPADQVNITE | FYNKSLSSFK | ENEENIQCGE | 
    150:
    NFMDIECFMV | LNPSQQLAIA | VLSLTLGTFT | VLENLLVLCV | ILHSRSLRCR | 
    200:
    PSYHFIGSLA | VADLLGSVIF | VYSFIDFHVF | HRKDSRNVFL | FKLGGVTASF | 
    250:
    TASVGSLFLT | AIDRYISIHR | PLAYKRIVTR | PKAVVAFCLM | WTIAIVIAVL | 
    300:
    PLLGWNCEKL | QSVCSDIFPH | IDETYLMFWI | GVTSVLLLFI | VYAYMYILWK | 
    350:
    AHSHAVRMIQ | RGTQKSIIIH | TSEDGKVQVT | RPDQARMDIR | LAKTLVLILV | 
    400:
    VLIICWGPLL | AIMVYDVFGK | MNKLIKTVFA | FCSMLCLLNS | TVNPIIYALR | 
    450:
    SKDLRHAFRS | MFPSCEGTAQ | PLDNSMGDSD | CLHKHANNAA | SVHRAAESCI | 
    472:
    KSTVKIAKVT | MSVSTDTSAE | AL
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    KEGG:
    MIM:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human CB-R
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    E15212r
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    ELISA Kit for Human CB-R
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    E15212h
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    Packing:
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    ELISA Kit for Human CB-R
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    E15212m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human CB-R
    Cat.:
    U15212h
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    Packing:
    96T
    CLIA Kit for Human CB-R
    Cat.:
    U15212m
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human CB-R
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    U15212r
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human CB-R
    Cat.:
    P15212Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human CB-R
    Cat.:
    P15212Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human CB-R
    Cat.:
    P15212Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human CB-R
    Monoclonal Antibody for Human CB-R
    Monoclonal Antibody for Human CB-R
    Protein for Human CB-R
    Protein for Human CB-R
    Protein for Human CB-R

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Nucleotide sequence of a human cannabinoid receptor cDNA."
      Gerard C. , Mollereau C. , Vassart G. , Parmentier M.
      Nucleic Acids Res.18:7142-7142(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain stem.
    2. 2.
      "Molecular cloning of a human cannabinoid receptor which is also expressed in testis."
      Gerard C. , Mollereau C. , Vassart G. , Parmentier M.
      Biochem. J.279:129-134(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain stem.
    3. 3.
      "An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing."
      Shire D. , Carillon C. , Kaghad M. , Calandra B. , Rinaldi-Carmona M. , Le Fur G. , Caput D. , Ferrara P.
      J. Biol. Chem.270:3726-3731(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
      tissue: Lung.
    4. 4.
      "Identification and characterisation of a novel splice variant of the human CB1 receptor."
      Ryberg E. , Vu H.K. , Larsson N. , Groblewski T. , Hjorth S. , Elebring T. , Sjoegren S. , Greasley P.J.
      FEBS Lett.579:259-264(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);FUNCTION;TISSUE SPECIFICITY
    5. 5.
      Kathmann M. , Schlicker E.
      Submitted (1998-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Hippocampus.
    6. 6.
      Bonner T.I.
      Submitted (1996-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    7. 7.
      Kumar S. , Gupta S. , Sharma G.
      Submitted (2005-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain tumor.
    8. 8.
      "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Kopatz S.A. , Aronstam R.S. , Sharma S.V.
      Submitted (2003-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    9. 9.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Hippocampus.
    10. 10.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    12. 12.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lung.
    13. 13.
      "CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a."
      Niehaus J.L. , Liu Y. , Wallis K.T. , Egertova M. , Bhartur S.G. , Mukhopadhyay S. , Shi S. , He H. , Selley D.E. , Howlett A.C. , Elphick M.R. , Lewis D.L.
      Mol. Pharmacol.72:1557-1566(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CNRIP1
      tissue: Brain.
    14. 14.
      "Effects of palmitoylation of Cys(415) in helix 8 of the CB(1) cannabinoid receptor on membrane localization and signalling."
      Oddi S. , Dainese E. , Sandiford S. , Fezza F. , Lanuti M. , Chiurchiu V. , Totaro A. , Catanzaro G. , Barcaroli D. , De Laurenzi V. , Centonze D. , Mukhopadhyay S. , Selent J. , Howlett A.C. , Maccarrone M.
      Br. J. Pharmacol.165:2635-2651(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION AT CYS-415
    15. 15.
      "Cannabinoid receptor-G protein interactions: G(alphai1)-bound structures of IC3 and a mutant with altered G protein specificity."
      Ulfers A.L. , McMurry J.L. , Miller A. , Wang L. , Kendall D.A. , Mierke D.F.
      Protein Sci.11:2526-2531(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 338-346
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